Mulberry Leaf DNJ

Mulberry Leaf DNJ

Botanical source: Morus alba L.
Part of Used: Leaf
Specification: 1.5% DNJ (Deoxynojirimycin)
Appearance: Brown Powder
CAS No.: 19130-96-2
Test Method: HPLC

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What is Mulberry Leaf DNJ?


Mulberry Leaf DNJ is a natural alkaloid whose Chinese name is 1-deoxynojirimycin. The medicinal value of mulberry leaves for people with diabetes and hyperglycemia lies in the DNJ component it contains.

The DNJ in mulberry is mainly distributed in the leaves, roots and branches of mulberry, and the content of DNJ in mulberry leaves is relatively high (about one thousandth of the dry weight). Moreover, mulberry leaves account for the largest proportion of the dry matter of the entire mulberry tree, which is about 65%. Therefore, mulberry leaves have become the main source for obtaining natural DNJ.

DNJ is a potent inhibitor of sugar metabolism enzymes (such as α-glucosidase), which can significantly delay the degradation process of polysaccharides, reduce the peak of postprandial blood sugar, which belongs to the "inhibitor" of the four major sugar control factors of Alpha.


DNJ Hypoglycemic Mechanism


Specification Sheet


Analysis

Specification

TEST METHOD

Appearance

Brown powder

Visual

Odor

Characteristic


Moisture

≤5.0%

USP

Ash

≤5.0%

USP

Particle Size

≥95%Through 80 mesh

USP

Part Used

Leaf


Bulk Density

40.0 g/100mL ~ 60.0 g/100mL


Total Heavy Metals

≤10ppm

USP

Cd

≤1.0ppm

ICP-MS

As

≤1.0ppm

ICP-MS

Pb

≤1.0ppm

ICP-MS

Hg

≤1ppm

ICP-MS

Assay

DNJ(Deoxynojimyricin)

1.5%

HPLC

Microbiology

Total Plate Count

≤1000cfu/g

USP34

Fungi and yeast

≤100cfu/g

USP34

E. Coli

Negative

USP34

Salmonella

Negative

USP34


Hypoglycemic Mechanism


As a highly effective inhibitor of glucose metabolism enzymes, Mulberry Leaf DNJ can control blood glucose levels through a multi-pronged approach:

(1) Lowers postprandial blood sugar. In the small intestine, DNJ reduces the binding probability of polysaccharides to α-glucosidase and inhibits the breakdown of fructose into glucose. Because of the action of DNJ, less glucose enters the bloodstream, so blood sugar levels can be maintained at healthy levels.

(2) Fasting blood sugar was stable. DNJ can slow down the process of hepatic glycogen degradation to glucose, thereby stabilizing fasting blood sugar.

(3) Improve insulin resistance. DNJ can increase insulin sensitivity and improve symptoms of insulin resistance.


Flow Chart


Flow Chart


Packing & Shipping


Packing & Shipping



Certificates


Certificate

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