Crocetin Powder

Crocetin Powder, or transcrocetin, is an orange-red to purple-red powder. It is one of the primary active ingredients of saffron and may also be found in the fruits of the Rubiaceae family plant known as a gardenia. With its polyunsaturated conjugated enoic acid structure, crocetin offers a variety of pharmacological properties, including antioxidant, liver protection, improved hypoxia resistance, improved vision, and so on. It is a valuable raw ingredient in dietary supplements, functional foods, cosmetics, and other products.

Saffron contains about 10% Crocetin and is the best-known and most-researched source of Crocetin. Therefore, many extract products claim to be based on saffron, but the price is extremely unreasonable. Saffron, also known as crocus, is a plant of the genus Crocus in the family Iridaceae. The medicinal part of saffron is the stigma, but the yield is very low. A flower has only three stigmas, ranging from a few millimeters to one or two centimeters. After dehydration, the weight of each one is less than 5 mg. Generally, only 1g of dry stigmas can be obtained from 200 flowers, meaning 1kg of dry stigmas can be obtained from 70,000 to 200,000 stigmas. So, saffron has a high price in the market and is known as "plant soft gold".

The main source of the best saffron is Iran, and the price is around $7000/kg, so what do you think about the extract? It is unrealistic for saffron, the most expensive spice in the world, to become a dietary supplement material for the masses.

Saffron is expensive and cannot be used as a raw material for Crocetin. However, we should know that it is the best source, but not the only one. Just like vitamin C, it is not only found in kiwis but also in oranges.

Gardenia fruit contains about 0.5% crocin, which can be converted into Crocetin. It is easy to obtain, low-priced, has a large planting scale, and is widely distributed in Zhejiang, Jiangxi, Hunan, Fujian, and Henan Provinces in China. Therefore, gardenia fruit has become the first choice for the industrial production of Crocetin Powder.

Since 2005, the Plant Resources and Natural Products Research Group of the Chinese Academy of Sciences has conducted research on the active ingredients in saffron and developed technology for producing crocetin from gardenia fruits. After years of accumulation, a production process for gardenia yellow pigment with a high color value (≥600) has been established, which solves the technical problems of Crocetin conversion, purification, stability, and poor water solubility, and produces high-purity saffron acid on a large scale successfully.

In August 2017, the project expanded its scale and achieved industrial production. The purity of Crocetin reaches 97.6%, which reduces the production cost of enterprises and increases the added value of gardenia. It is of great significance to promote the development of the gardenia industry.

The therapeutic properties of gardenia fruit have made it a valuable ingredient in traditional Chinese herbal medicine for centuries. Gardenia fruit contains crocetin, a naturally occurring carotenoid well-known for its vivid color and possible health benefits. The crocetin extract powder from gardenia fruit has drawn interest due to its many health benefits.

 Anti-Inflammatory and Immunomodulatory Effects

Crocetin significantly reduces pro-inflammatory cytokines like TNF-α and IL-6, which are linked to chronic inflammation in conditions such as metabolic syndrome, cardiovascular diseases, and neurodegenerative disorders. A meta-analysis of randomized controlled trials confirmed that crocetin supplementation lowers hs-CRP (a marker of systemic inflammation) and oxidative stress. It also modulates immune responses by inhibiting NF-κB signaling, a key pathway in inflammation.

 Antioxidant and Cellular Protection

Crocetin neutralizes free radicals and enhances total antioxidant capacity (TAC) by upregulating enzymes like superoxide dismutase (SOD) and catalase (CAT). It protects against oxidative damage in:

a. Cardiovascular diseases: Reduces LDL oxidation and improves endothelial function.

b. Neurodegenerative diseases: Shields neurons from oxidative stress in Alzheimer's and Parkinson's.

c. Diabetes: Lowers advanced glycation end-products (AGEs) linked to diabetic complications.

 Neuroprotective and Cognitive Benefits

a. Alzheimer's disease: Crocetin inhibits amyloid-beta aggregation and synaptic loss, improving memory in clinical trials.

b. Depression and anxiety: Enhances serotonin and BDNF levels, with efficacy comparable to antidepressants like fluoxetine but with fewer side effects.

c. Age-related macular degeneration (AMD): Protects retinal cells from oxidative damage, improving visual acuity.

 Metabolic and Cardiovascular Health

a. Diabetes: Reduces fasting blood glucose and improves insulin sensitivity in animal and human studies.

b. Obesity: Lowers triglycerides, BMI, and waist circumference while increasing HDL cholesterol.

c. Atherosclerosis: Decreases oxLDL and vascular adhesion molecules (VCAM-1, ICAM-1) to prevent plaque formation.

We promise to produce and offer our global customers high-quality, safe, and highly bioavailable herbal extracts (powder, oil, liquid, etc.) as an experienced and skilled manufacturer and supplier. With many international certifications, including ISO, FDA, Kosher, Halal, FSMA, BRC, and others, we can guarantee that the finished herbal extracts we sell meet stringent quality, potency, and purity criteria.

Owing to our full adherence to the previously stated international certifications, our clients throughout the globe may be certain of the excellent bioavailability, safety, and efficacy of the herbal extracts we provide. When our clients wish to work with an outstanding and dependable provider of premium herbal extracts, they can rest easy knowing that we are committed to maintaining the aforementioned certifications.

Here are the product applications of Crocetin Powder in dietary supplements, functional foods, and cosmetics:

 Dietary Supplements

a. Nutraceutical Formulations: Crocetin is used in dietary supplements and nutraceuticals for its bioactive properties, often encapsulated or formulated into tablets and tablets.

 Functional Foods

a. Natural Food Colorant: Crocetin imparts a yellow-orange hue to foods and beverages, serving as a natural alternative to synthetic dyes.

b. Flavor and Aroma Enhancer: Used in saffron-based spices, confectioneries, and beverages for its distinctive flavor profile.

c. Functional Ingredient: Incorporated into health-promoting foods like fortified cereals, energy bars, and dairy products for its antioxidant properties.

 Cosmetics

a. Skin Brightening Agent: Crocetin is used in creams and serums for its potential to enhance skin radiance and even tone.

b. Anti-Aging Formulations: Included in anti-aging products due to its antioxidant activity, which may support skin elasticity.

c. Natural Cosmetic Dye: Employed in lipsticks and makeup products as a safe, plant-derived coloring agent.

Here are some common frequently asked questions (FAQs) about crocetin extract powder:

If you would like to know more about this product, please get in touch with us at bella@inhealthnature.com.

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