What Are The Potential Benefits Of Fisetin？

Where is Fisetin found in?

Fisetin 50% Extract Powder is usually separated from Cotinus coggygria, a plant widely grown in China. Moreover, Fisetin is a substance that occurs naturally in fruits and vegetables, such as strawberries, apples, grapes, onions, and cucumbers. The Fisetin content of fresh fruits and vegetables may vary, depending on the conditions in which they were grown.

How does Fisetin work?

To begin with, Fisetin directly neutralizes free radicals and increases other powerful antioxidants, such as glutathione, superoxide dismutase, catalase.

In addition, Fisetin blocks a pathway called NF-κB. NF-kB is a factor that trigger genes to bring about inflammatory compounds. An overactive NF-κB response is associated with allergies, autoimmune diseases, and cancer. Furthermore, fisetin blocks inflammatory enzymes that degrade fatty acids.

In conclusion, Fisetin also blocks the mTOR pathway. An overactive mTOR response has been linked to cancer, diabetes, obesity, and neurodegenerative diseases. By blocking this pathway, fisetin helps remove waste and enhances cellular metabolism.

What is Fisetin good for?

Besides reserve aging and longevity, recent research found that fisetin has other powerful properties, such as controlling blood sugar level of diabetic symptoms, brain protection and prevention of neurodegenerative diseases, relieving pain, skin protection, and so on.

★ Diabetes and Complications

In multiple animal studies, Fisetin can improve their ability to control blood sugar levels by: 1) increasing insulin levels; 2) increasing enzymes that convert sugar into energy; 3) removing sugar from the blood to store as glycogen in the liver; 4) decreasing the liver’s ability to make sugar from lactate and amino acids.

Another complication of diabetes is arteriosclerosis and heart disease. In a cell study, fisetin prevented inflammation in blood vessels caused by high sugar levels. Diabetes often causes nerve damage and pain. Fisetin reduces pain sensitivity in diabetic and nerve-damaged mice.

★ Brain Protection

Fisetin also has a positive effect on brain functioning and brain aging. For example, fisetin can improve memory formation in mice.

★ Neurodegenerative Disease

Immune cells in the brain called microglia are overactivated in neurodegenerative diseases such as Alzheimer's and Huntington's. This can lead to inflammation and damage to healthy brain cells. In cell studies, fisetin boosts brain antioxidant levels and prevents microglia from releasing inflammatory compounds in response to bacterial toxins

★ Skin Protection

Interestingly, fisetin also has multiple beneficial effects on the skin. For example, fisetin can reduce the formation of skin wrinkles and the appearance of skin aging.

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