NAD Powder
Cellular Health Booster Ingredient
Pure and Additive-Free Ingredient
Bulk NAD+ Powder Manufacturer
Premium Quality, Competitive Price, and Excellent Service
CAS No.: 53-84-9
Specification: 99.0%
Appearance: White to off-white powder
Production technology: Enzymatic
Origin: China
Test method: HPLC
Package: 1kg/bag, 5kg/bag, 25kg/drum
Lead time: 5 days after payment is received
Certificate: ISO, FSSC, KOSHER, HALAL
MOQ: 5kg
Free Sample: 10-20g
Shaanxi Inhealth Nature Industry Co., Ltd. is one of the most experienced manufacturers and suppliers of nad powder in China, featured by quality products and good price. Welcome to wholesale bulk high-grade nad powder from our factory. Contact us for free sample.
Bulk NAD+ powder manufacturer
NAD Powder is the oxidized form of this essential coenzyme, supplied as a high-purity lyophilized powder. It is a white to off-white, free-flowing powder with excellent water solubility, allowing for easy incorporation into various formulations. The human body requires NAD because it is a critical coenzyme in every living cell; levels decline naturally with age. Maintaining adequate NAD is essential for mitochondrial energy production, DNA repair mechanisms, and the activation of sirtuins that regulate cellular health and longevity. Its high solubility and stability make NAD bulk powder suitable for a wide range of applications and dosage forms, including powders, capsules, tablets, liposomal formulations, topical serums, and functional beverages. We utilize enzyme catalysis combined with chromatographic purification to produce premium NAD bulk powder. This production process imparts the following features to our powder:
High Purity: Our enzyme-catalyzed synthesis produces NAD ingredient with exceptional quality, while chromatographic purification removes process-related impurities, achieving purity exceeding 99% verified by HPLC analysis.
Superior Stability: The gentle enzymatic reaction conditions and optimized lyophilization process preserve molecular integrity, resulting in a stable powder with consistent quality.
Controlled Physical Properties: Our manufacturing process yields a white to off-white powder with optimized particle characteristics, ensuring excellent flowability and solubility for ease of formulation.
Batch-to-Batch Consistency: Strict process controls and in-process testing guarantee reproducible quality across all production batches.
Comprehensive Documentation: Each batch is accompanied by a Certificate of Analysis, including HPLC purity data, impurity profiles, and stability information.
As a trusted NAD bulk powder manufacturer, Inhealth Nature provides comprehensive OEM solutions tailored to the specific needs of dietary supplement, nutraceutical, skincare, and pharmaceutical industries.
a. Custom Formulation Development: We work with clients to develop finished products in various dosage forms based on high-purity NAD ingredient.
b. Flexible Packaging Options: From small-scale trial batches to bulk industrial packaging, we offer customized packaging solutions that meet your brand requirements and market positioning.
c. Full Regulatory Support: Our facility operates under strict quality management systems, with ISO, FSSC, Kosher, and Halal certifications available to support your market entry requirements.
d. Turnkey Manufacturing: We manage the entire production process from raw material sourcing through formulation, filling, labeling, and final packaging, delivering finished products ready for commercial distribution.
e. Quality Assurance: Every batch undergoes rigorous testing for purity, potency, and stability, ensuring that your final products consistently meet the highest quality standards.
specification sheet
|
ITEM |
SPECIFICATION |
RESULT |
|
Organoleptic |
||
|
Appearance |
White to off-white powder |
Conform |
|
Purity: (by HPLC) |
||
|
NAD |
≥95.0% |
99.60% |
|
Physical and Chemical |
||
|
Water content |
＜10.0% |
4.50% |
|
Contaminants |
||
|
Arsenic (As) |
＜0.15 ppm |
Conform |
|
Cadmium (Cd) |
＜2.5 ppm |
Conform |
|
Lead (Pb) |
＜0.5 ppm |
Conform |
|
Mercury (Hg) |
＜1.5 ppm |
Conform |
|
Ethanol (by GC) |
＜5000ppm |
110ppm |
|
Microblological |
||
|
Total microbial count |
＜750cfu/g |
70cfu/g |
|
Coliform |
＜3.0MPN/g |
Negative |
our production process
We utilize an enzyme-catalyzed synthesis combined with chromatographic purification. Our high-purity NAD bulk powder with optimized physical properties (high bulk density and excellent flowability) is suitable for dietary supplements, nutraceuticals, and skincare applications.
Step 1: Reaction & Synthesis
a. Raw Materials: Nicotinamide Riboside (NR), ATP, biocatalysts (enzyme system), cofactors, buffer solution, and water.
b. All the raw materials are added to a bioreactor. At controlled temperatures between 30 and 37°C, the enzymes catalyze the conversion of NR and ATP to NAD. ATP serves as the phosphate donor, and this single-step biocatalytic process provides high selectivity while producing very few byproducts.
Step 2: Primary Filtration
The reaction mixture undergoes a filtration process to remove insoluble impurities, including residual enzymes, cell debris (if applicable), and unreacted particulates, yielding a clarified NAD solution.
Step 3: Chromatography on Resins
The filtrate is passed through columns packed with specialized resins (e.g., ion-exchange chromatography or HPLC-grade media). This is the core step for achieving high purity levels. It effectively separates the target NAD from process-related by-products, other nucleotides (such as residual ATP, ADP, and AMP), organic impurities, and residual salts.
Step 4: Concentration
The purified NAD solution is concentrated under reduced pressure using vacuum concentration. This step increases the product concentration to prepare the solution for freeze-drying, thereby shortening the processing time in the following drying phase.
Step 5: Lyophilization (Freeze-Drying)
The concentrated NAD solution is placed into a freeze-dryer. It is first frozen at -60°C, then dried under a vacuum of 50 pascals or less for at least 20 hours. This process eliminates water through sublimation, maintaining the NAD molecule's structure and stability, resulting in a white to off-white lyophilized powder with high solubility.
Step 6: Milling and Sieving
The lyophilized powder may be milled and sieved to achieve a uniform particle size. This step optimizes physical properties such as bulk density and powder flowability, facilitating handling and blending in downstream formulations.
Step 7: Quality Control
The final NAD bulk powder undergoes comprehensive quality testing. High-performance liquid chromatography is used to verify purity (>99%), impurity profiles, and content uniformity. Additional tests are conducted for residual moisture and heavy metal content to ensure compliance with specifications.
Step 8: Packaging
The dried NAD bulk powder is packaged in airtight containers (e.g., aluminum foil bags) under strict clean area conditions. This prevents re-exposure to moisture, oxygen, or microbiological contaminants and ensures the product maintains its purity and physical properties throughout its shelf life.
Health benefits of NAD+ powder
NAD Powder supplements aim to boost declining cellular NAD levels, potentially enhancing energy metabolism, improving cognitive function, and slowing age-related decline. Key health benefits often associated with NAD supplementation include:
1. Increased Energy and Metabolism: NAD plays a vital role in generating adenosine triphosphate (ATP), the energy source for cells. Raising NAD levels can improve mitochondrial performance, leading to increased energy and reduced fatigue. Research on NAD precursors indicates possible benefits for managing blood sugar and cholesterol, although direct proof for NAD supplements is still developing.
2. Anti-Aging and Longevity Support: NAD levels drop with age, contributing to cellular dysfunction. Increasing NAD levels helps activate sirtuins, proteins that regulate cellular health and repair DNA, potentially supporting healthy aging and longevity.
3. Cognitive Protection and Brain Health: By reducing inflammation and oxidative stress, NAD may protect neurons and support healthy brain aging, with potential protective effects against neurodegenerative conditions such as Alzheimer's and Parkinson's (primarily supported by preclinical studies; human evidence is limited).
4. Muscle and Tissue Repair: NAD supplementation, particularly using precursors like NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide), may improve muscle health, strength, and recovery, combating age-related muscle loss (sarcopenia).
5. Skin Health and Regeneration: NAD promotes DNA repair and protects against cellular damage, which can help maintain skin elasticity and structure.
multiple product applications
NAD Powder is primarily utilized in the wellness, anti-aging, and pharmaceutical industries to boost cellular NAD levels, which naturally decline with age. It is used as a foundational ingredient in products targeting mitochondrial function, DNA repair, and energy metabolism. Here are the main product applications of this powder:
Dietary Supplements (Capsules and Powders)
NAD bulk powder is frequently used in oral supplements, sometimes combined with precursors like NMN or NR to provide multiple pathways for NAD elevation. (Note: Oral absorption of NAD itself remains limited; sublingual or liposomal formulations are often preferred.)
a. Anti-Aging and Longevity: Products designed to support mitochondrial health and sirtuins, enzymes that regulate aging.
b. Energy Management: Targeted at increasing ATP production to combat fatigue and improve endurance.
c. Cognitive Support: Used in supplements aiming to reduce neuroinflammation and improve focus (primarily supported by preclinical research).
d. Metabolic Health: Research on NAD precursors suggests potential benefits for insulin sensitivity.
Topical Skin Care (Creams and Serums)
NAD is used in high-end anti-aging skincare products.
a. Anti-Wrinkle and Repair: Topical NAD aims to reduce age-related dermal dysfunction by supporting skin cell rejuvenation and protecting against UV damage.
b. Skin Barrier Enhancement: Products formulated to enhance hydration and support the regenerative capacity of skin stem cells.
Pharmaceutical and Compounding Formulations
Compounding pharmacies use high-purity NAD bulk powder to create personalized, regulated, or prescription-strength applications.
a. IV Therapy and IM Shots: NAD is dissolved into a sterile saline solution for intravenous (IV) or intramuscular (IM) injection to directly deliver the nutrient into the bloodstream, bypassing the digestive system.
b. Nasal Sprays: Used in prescription formulations to provide rapid delivery for mental clarity (stability and absorption challenges remain formulation-dependent).
HPLC analysis Fingerprint
Superior Purity
The powder achieves a chromatographic purity of greater than 99.5 percent, which exceeds the typical range of commercially available NAD+ powders. The single-peak profile confirms that the active ingredient constitutes the overwhelming majority of the product mass.
Exceptional Impurity Control
No process-related impurities such as residual ATP, ADP, AMP, or nicotinamide riboside are detected. No degradation products are observed, demonstrating effective purification and excellent chemical stability. The biocatalytic synthesis ensures exclusive formation of the biologically active beta-anomer, eliminating the risk of inactive or potentially interfering isomers.
Outstanding Stability
The absence of degradation peaks confirms that the NAD molecule remains intact under the tested conditions. This stability supports extended shelf life when stored properly and ensures consistent performance in downstream applications such as enzymatic assays, formulation development, and long-term research studies.
Advanced and Sustainable Manufacturing
The product is manufactured using a state-of-the-art biocatalytic process based on the nicotinamide riboside plus ATP route. This one-step enzymatic synthesis minimizes byproducts, simplifies purification, and incorporates an ATP regeneration system that significantly reduces production costs. The process operates under aqueous, mild conditions without the use of toxic organic solvents, aligning with green chemistry principles.
Broad Application Suitability
The combination of high purity, excellent stability, and reliable analytical documentation makes this NAD bulk powder suitable for a wide range of demanding applications. It is well-suited for use as a research-grade reagent, a reference standard in enzymatic assays, a high-quality active ingredient in premium nutraceuticals, and a stable component in cosmetic formulations targeting cellular energy and anti-aging benefits.
our factory
Our factory operates in a controlled environment, where scientific precision meets sustainable methods to yield high-purity bioactive compounds. Every phase of the process, beginning with raw material sourcing and extending through final product formulation, maintains the full integrity of botanical ingredients.
1. Precision Processing: Customized extraction methods (water, ethanol, or solvent-based) are tailored to each plant's chemistry, maximizing yield without compromising potency.
2. Quality Assurance: In-house labs conduct rigorous testing for contaminants, heavy metals, and active compound concentration, aligning with international standards like USP and EP.
3. Flexible Capabilities: The facility accommodates diverse client needs, from small-batch extracts to large-scale commercial production.
4. Sustainability Focus: Waste reduction systems, energy-efficient machinery, and solvent recovery processes show our commitment to eco-conscious manufacturing.
our certificate
As an experienced and skilled manufacturer and supplier, we pledge to produce and offer our global customers superior herbal extracts (powder, oil, liquid, etc.) that are safe and have a high bioavailability. Due to our several international certifications, including ISO, FSSC, FDA, Kosher, Halal, FSMA, and others, we can ensure that the final herbal extracts we sell adhere to strict standards and regulations regarding potency, quality, and purity.
Because of our complete compliance with the aforementioned international certifications, our clients worldwide can be certain of the safety, effectiveness, and high bioavailability of the herbal extracts we offer. When clients seek to collaborate with an outstanding and dependable provider of premium herbal extracts, our commitment to the aforementioned certifications offers them peace of mind.
FAQ
Q1: Why can't I just take NAD orally in pill form?
A: NAD is a large, fragile molecule that does not survive digestion intact. When taken orally, it faces several barriers:
a.Stomach acid breaks it down
b.Digestive enzymes dismantle it further
c.It cannot cross the intestinal walls intact due to its size and polarity
d.The liver alters any remaining fragments via first-pass metabolism
This is why most supplements use precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) instead of direct NAD. These smaller molecules survive digestion better and enter cells to be converted into NAD.
For direct NAD supplements, sublingual administration (dissolving powder under the tongue) is sometimes recommended to bypass the stomach and liver. While this avoids first-pass breakdown, the evidence for sublingual NAD significantly raising intracellular NAD levels is less established compared to oral precursors.
Q2: How do I choose a high-quality NAD⁺ powder?
A: Look for these quality indicators:
1) Third-party testing: A Certificate of Analysis (CoA) from an independent lab verifying purity (≥99% is ideal for NAD⁺).
2) Transparency: The brand openly provides test results, ideally with the lab name and date.
3) GMP certification: Indicates the product is manufactured under current Good Manufacturing Practices.
4) Proper packaging: Airtight, opaque containers that protect the powder from moisture and light, as NAD⁺ is hygroscopic and light-sensitive.
5) No unnecessary fillers: Pure powder with minimal additives.
Q3: Can I take NAD bulk powder with other supplements?
A: Generally, yes. NAD works well alongside many supplements, and some combinations may have synergistic effects:
a. Resveratrol or pterostilbene: May enhance sirtuin activation
b. CoQ10: Supports mitochondrial health
c. B vitamins: Essential for NAD metabolism
However, compatibility should be tested, especially in complex blends. If you are on medications, consult your healthcare provider first.
Q4: What is the difference between NAD⁺ and NADH?
A: NAD⁺ (nicotinamide adenine dinucleotide, oxidized form) and NADH (nicotinamide adenine dinucleotide, reduced form) are the two forms of the same essential coenzyme. They are interconverted in living cells through redox reactions and serve distinct but complementary roles in metabolism.
NAD⁺ functions primarily as a signaling molecule and a substrate for enzymes such as sirtuins and PARPs, which are involved in DNA repair, epigenetic regulation, and cellular stress responses. It is the predominant form in cells under normal physiological conditions and is required for the activity of enzymes that consume NAD⁺ to carry out their functions.
NADH functions primarily as an electron carrier. It is generated during catabolic reactions such as glycolysis and the tricarboxylic acid cycle, and it donates electrons to the electron transport chain for ATP synthesis. NADH is the reduced, high-energy form of the coenzyme.
Q5: How long does a container of NAD⁺ powder last once opened?
A: Once opened, NAD⁺ powder should ideally be used within 3 to 6 months, provided it is stored properly, tightly sealed, refrigerated, and protected from light and moisture. Frequent opening and exposure to humidity can accelerate degradation.
To maximize shelf life after opening:
1) Store in the original airtight, opaque container
2) Keep refrigerated at all times
3) Before opening, allow the container to reach room temperature (still sealed) to prevent condensation from forming inside
4) Avoid touching the powder with wet or unwashed utensils
5) Minimize the time the container is open during use
Signs of degradation:
a. Clumping or hardening of the powder
b. Yellowing or darkening from the original white color
c. If these signs appear, potency may be reduced even if the powder is within the 3–6 month window.
Q6: Can NAD⁺ powder be used in topical skincare formulations?
A: Yes, NAD⁺ is increasingly being incorporated into anti-aging skincare products. As a molecule involved in cellular energy metabolism and DNA repair, it may theoretically support skin cell function and help reduce visible signs of aging when delivered effectively to skin cells.
However, there are important considerations when formulating with NAD⁺ for topical use:
1) Molecular size and absorption: NAD⁺ has a molecular weight of approximately 663 Da and carries a negative charge, which limits its ability to cross the stratum corneum. Effective delivery to viable skin layers may require advanced formulation strategies such as liposomes, microemulsions, or permeation enhancers.
2) Solubility: NAD⁺ is water-soluble, making it suitable for serums, aqueous creams, and lotions.
3) pH: Formulations should be adjusted to a skin-friendly pH range (approximately 5.0–6.0) to minimize irritation and maintain stability.
4) Stability in solution: NAD⁺ is significantly less stable in aqueous formulations than in powder form. Finished products should be protected from light and heat, and may benefit from stabilizing agents (e.g., chelators, antioxidants) or dual-chamber packaging to maintain potency.
5) Typical use levels: 0.1% to 1% is a common concentration range, though optimal levels depend on formulation type, stability testing, and intended function.
Q7: How is NAD+ powder shipped and stored during transit?
A: To maintain stability during shipping:
a. NAD+ powder should be shipped with temperature control (cool packs or insulated packaging), especially during summer months
b. Overnight or expedited shipping is preferred to minimize time in transit
c. Upon receipt, store immediately in the refrigerator
d. If the package feels warm upon arrival, check for signs of degradation (color change, clumping) and contact the supplier if concerns arise
our OEM Service
At Inhealth Nature, we offer end-to-end OEM solutions for NAD+ powder products, ensuring your brand receives premium formulations tailored to your specifications and market demand. We can provide powders, capsules, tablets, liposomal formulations, and topical serums. You can trust us for the following reasons:
Turnkey Solutions: From raw NAD+ powder sourcing to finished products
Flexible MOQs: Small batches for startups to bulk production
Certified Quality: ISO, FSSC, Kosher, and Halal options available
Market-Ready: Fast formulation for trending niches (cellular health supplements, anti-aging nutraceuticals, energy support formulations, cosmetic serums, and functional beverages)
The following is the process of our OEM service:
you can find us here
If you have any ingredient and formulation needs or require a quote, our sales team is ready to assist you.
Shaanxi Inhealth Nature Industry Co., Ltd.
Tel: +86-29-88387688
Mobile/WhatsApp: +86 18202932679
Email: kathy@inhealthnature.com
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